Suitability of ?1-microglobulin reduction rate as a biomarker of removal efficiency of online hemodiafiltration: a retrospective cohort study

Abstract Background Online hemodiafiltration (OL-HDF), whether in pre-dilution OL-HDF (pre-HDF) or post-dilution (post-HDF), is conducted to efficiently remove low molecular weight proteins from the blood of patients requiring dialysis. ? 2 -microglobulin (? -MG) and ? 1 (? are used as biomarkers evaluate removal efficiency OL-HDF. We aimed relationship between -MG reduction rates amount albumin leakage. Furthermore, we statistically analyzed rate amount, its suitability a biomarker for evaluating Methods collected results regularly routine evaluations assess cases undergoing maintenance dialysis at our clinic 2018 2019. Data on was both pre-HDF post-HDF sessions. were analyzed. Regression analysis showed significant correlation amount. Results 435 tests 87 There 80.7 ± 4.5% rate, 33.8 9.4% 3.9 1.8 g/s no leakage rate. Conclusion found correlate with demonstrating Trial registration Retrospectively registered.